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Assistant/Associate/Full Project Scientist - Instrumentation Microscopy – Advanced Bioimaging Center – Department of Molecular and Cell Biology
The Advanced BioImaging Center (ABC) in the Department of Molecular and Cell Biology at the University of California, Berkeley seeks applications for two Project Scientist at the Assistant, Associate, or full rank. The selected candidate will be appointed at the rank to commensurate with prior experience. The position will report to Professor Gokul Upadhyayula, with Professor Eric Betzig serving as an additional academic mentor. The project scientist will make significant and creative contributions in the area of molecular and cellular microscopy research. The Advanced BioImaging Center (ABC) at UC Berkeley aspires to be a world-leading multidisciplinary imaging center that drives important biological discoveries through critical new advances in all aspects of imaging technology and that drives the dissemination of that technology through a multi-pronged education strategy to scientists around the world. ABC was intentionally designed to maximize scientific productivity and impact by adopting groundbreaking imaging technologies such as the next-generation adaptive optical multifunctional microscope, incorporating the high-level technical expertise of instrumentation scientists, applied mathematicians, and computational scientists, and building worldwide collaborations aimed at tackling the challenges posed by terabyte and petabyte-scale imaging data processing, visualization, and dissemination. Members of the ABC have access to leading - edge imaging and computing hardware, as well as exposure to collaborators from a range of diverse disciplines, including in the fields of Artificial Intelligence, Data Science, Mathematics, and more. The purpose of this project is to develop a foundation AI model capable of extracting biological insights from 4D (x,y,z,time) datasets of subcellular dynamics within physiological contexts and across scales. Incumbent will advance imaging to generate petabytes of targeted and high quality datasets necessary to prototype and build this model. The Assistant/Associate/Full Project Scientists will help develop and execute the research program focused around ABC’s overarching goal of moving cell biology away from the coverslip and into physiological systems. These positions will work within a dedicated team to develop and refine the microscopy techniques. This position will manage projects and provide regular progress reports to PIs and collaborators. The incumbent will spend 90% of their time on ABC research goals and managing and maintaining equipment in the lab and 10% of their time training/supervising collaborators, graduate students and postdoctoral fellows on MOSAIC/iAOLLSM capabilities. Key responsibilities: These positions are eligible for full benefits.
•Make significant and creative contributions to designing, building, and testing of a new high throughput adaptive optical inverted lattice light-sheet microscope (iAO-LLSM). This instrument aims to achieve a 10-fold increase in data acquisition throughput while maintaining the high-quality optical performance demonstrated in our previous work.
•Use, maintain, and oversee the operations of the two next-generation multimodal optical scopes with adaptive imaging correction (MOSAIC) microscopes at the ABC.
•Actively participate in handling/mounting biological samples on advanced microscopes and collect 4/5D datasets.
•Collaborate with a cross-disciplinary team of AI scientists, data engineers, instrumentation scientists and biologists and generate high resolution microscopy data using novel transparent developing organism reagents necessary to reach the goal of prototyping and training a 4D foundation model.
•Actively participate in national and international collaborations, presentation of research findings at scientific conferences, and publication of results in leading peer-reviewed journals.
•The incumbent will actively participate in and occasionally lead efforts to develop new projects.